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Ulinski et al

Cardiopulmonary complications Alcohol affects the heart and lungs

Aminoacridine, abemaciclib, and proflavine notably increased expression levels of RSPO3 and RSPO4 genes, with aminoacridine notably enhancing RSPO3 levels by 19-fold, the highest among tested drugs

These charms have different chemical properties that allow them to interact in different ways w/one another (important for the protein to fold properly) & with other molecules (important for intracellular interactions)